The Nutrition for Precision Health study leverages the large and diverse data platform of the NIH’s All of Us research program.
National Institutes of Health grants $ 170 million over five years, pending fund availability, to clinics and centers across the country for a new study that will develop algorithms to predict individual responses to dietary and dietary routines . Precision Health Nutrition driven by the All of Us (NPH) research program will recruit a diverse group of 10,000 participants who are part of the NIH’s All of Us research program to report more personalized nutritional recommendations.
The initiative includes 11 new awards and provides additional funding for three awards from the NIH Research Program. NPH is a NIH-wide effort managed by the NIH Common Fund and the first independent study to invite multiple participants in the All of Us program.
“We know that nutrition, like medicine, is not a one-size-fits-all measure,” said Holly Nicastro, Ph.D., MPH, NPH coordinator. “NPH will take into account an individual’s genetics, gut microbes, and other biological, environmental, or social lifestyle factors to help each individual develop dietary recommendations that improve overall health.”
An important challenge in precision nutrition is the inability to combine the many factors that affect the way people respond to diet into a personalized nutrition regimen. These potential factors include the microbiome, the community of microbes that live in our gut, metabolism, nutritional status, genetics, and the environment. How these factors interact to affect health is still poorly understood.
To address these gaps, NPH will collect new data on multiple potential predictors and combine them with existing data in the All of Us database to develop a more complete picture of how people respond to different foods or dietary routines. Through the development of this major precision nutrition research study, NPH will complement the ongoing nutrition research efforts at the NIH and implement components of the 2020-2030 Strategic Plan for NIH Nutrition Research. NPH data will be integrated into the All of Us Researcher Workbench and will be widely available to enable researchers to make discoveries that could improve health and prevent or treat diseases and conditions affected by nutrition.
“The All of Us research program was designed to support a wide range of studies by providing the infrastructure for a large and diverse data set that was previously unavailable,” said Josh Denny, MD, CEO of All of Us. “We are delighted that we all have a role to play in advancing in-depth nutritional research and promoting precision nutrition as a platform for this unique initiative.”
We will all provide existing data from participants who agree to participate in the NPH study, such as genomics, linked electronic health records, and survey data, such as information about daily life experiences, family health, and more. . These data links will make NPH one of the largest and most diverse precision nutrition studies to date.
The NPH program includes several institutes and centers within the NIH, including the NIH Common Fund; Research program All of us; Office of Nutrition Research; National Institute of Diabetes and Digestive and Renal Diseases; National Heart, Lung and Blood Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; the National Cancer Institute; and the National Center for Advancing Translational Sciences.
The 14 awards will establish the NPH consortium, which includes six clinical centers, a dietary assessment center, a metabolomics and clinical trials center, a microbiome and metagenomics center, a data modeling and multimodal bioinformatics center, and a coordination center. ‘additional research and support to all existing ones. infrastructure of us.